Dr Angus Lindsay is focused on unravelling the intricate mechanisms behind neurological and striated muscle dysfunction in muscle diseases.
His team delves into the complexities of conditions such as Duchenne, Becker, limb-girdle and FSHD (facioscapulohumeral) muscular dystrophies, as well as amyotrophic lateral sclerosis.
Angus’ research employs genetic editing and state-of-the-art tools like mass spectrometry for molecular analysis, in vivo and ex vivo contractility assessments for physiological studies, and advanced bio-imaging techniques (fMRI, PET and spectral-CT).
Angus and his team are exploring metabolic pathways related to neurological dysfunction in muscular dystrophies. Additionally, they are investigating the molecular mechanisms that drive hyper-sensitivity to eccentric contractions in dystrophic muscle.
While currently based at the University of Canterbury with an Honorary position at the University of Otago, Angus has held academic positions at Deakin University in Australia and the University of Minnesota in the USA.
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