“As a mum of a little one with cystic fibrosis, it scares me where we would be without antibiotics.
Isabella relies on them to keep the bugs at bay in her lungs and inhales them every day. She also has gastrointestinal failure and needs antibiotics to keep bacteria levels down.
Without them she is in huge pain that recently required ketamine as a pain relief.
What scares me most as a mum reliant on antibiotics is that she will start developing an immunity to them. They are a vital part of my girl living a full life.”
– Alley, Isabella’s mum.
Cystic fibrosis is an inherited lung condition which also affects many of the internal organs. The abnormal production of mucus in the lungs and pancreas creates the perfect breeding ground for dangerous and difficult to treat bacteria.
Chronic respiratory infection is a major cause of life-limiting illness and even death for those with cystic fibrosis. Often the infection is caused by a bug known as Pseudomonas aeruginosa. As Pseudomonas becomes increasingly resistant to antibiotics, those with cystic fibrosis are put at greater risk.
The discovery of new antibiotics is critical to maintaining the health of those most susceptible to infection.
Pseudomonas aeruginosa is a bug of particular focus for Dr Wiles because of how difficult it is to combat, and the threats it poses to people with cystic fibrosis.