For the past 25 years, Professor Tony Kettle has investigated the enzymology of myeloperoxidase (MPO).
This haem protein gives pus and phlegm their characteristic green tinge and produces chlorine bleach from hydrogen peroxide and common salt.
The knowledge gained from Professor Kettle's research has provided insight into how white blood cells called neutrophils use MPO to kill bacteria. It has also revealed that chlorine bleach and free radicals contribute to inflammation.
Professor Kettle's studies have shown that chlorine bleach promotes inflammatory tissue damage in conditions such as cystic fibrosis, asthma, rheumatoid arthritis, and cardiovascular disease. In collaboration with AstraZeneca, he has also developed specific inhibitors of MPO that have the potential to serve as anti-inflammatory drugs.
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