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Neurological Conditions

We're currently researching into Neurological Conditions

450 children develop epilepsy each year, dramatically reducing their quality of life and often resulting in death. Batten disease is a very rare inherited neurological disorder in children with no cure, nor effective treatments, and it invariably ends in premature death.

In Progress

A computer model to adjust the insulin dose in preterm babies with high blood sugar levels

A computer programme that helps to keep blood sugar levels in a safe range for preterm babies treated with insulin, to help avoid brain damage after preterm birth.

Effect of early probiotics on childhood cognition and behaviour

Will children whom of which were given probiotics as infants (as were their mothers in pregnancy) have reduced risk of cognitive, behavioural and mood problems at 11 years-of-age?

A follow-up of a national birth cohort from 1986. An investigation into the long-term effects associated with being born very preterm with very low birthweight (VLBW).

A follow-up of a national birth cohort from 1986. An investigation into the long-term effects associated with being born very preterm with very low birthweight (VLBW).

Investigating a novel gene therapy in a form of Batten disease

Using an alternative treatment to combat CLN6 Batten disease in a naturally occurring mouse model.

A quest to find the genes responsible for childhood epilepsies

This project is discovering causative genes in epilepsies which help with diagnosis and treatment.

Towards human translation of gene-therapy for Batten disease

This project will refine current methods of gene therapy in a sheep model with the aim of expediting the therapy to clinical trials.

Recently Completed

Are babies treated with dextrose gel, a measure for reducing low blood sugar in babies, symptom-free at two years of age?

A study of children at two years of age assessing whether there are any adverse effects eventuating from the dextrose gel used to treat their hypoglycaemia at birth.

Innovative therapies for Batten disease and childhood epilepsy

Can the use of cannabis-derivatives reduce the distressing symptoms associated with Batten disease and other childhood epilepsies?

A novel gene therapy for Batten disease

Gene therapy that has proved successful in preclinical trials for one form of Battens diseases will now be tested in another form with the hope that if successful, the method can too move forward to clinical trials.