Dr Tanya and her team are focused on Duchenne muscular dystrophy (DMD) a genetic disease that leads to progressive weakness and eventual cardiac and respiratory failure.
Tanya's research focus is to quantify the levels and movements of calcium and reactive oxygen species (ROS) within the triadic microdomain and bridge the knowledge gap in calcium and ROS crosstalk.
At rest, these two processes must interact to maintain muscle at the ready for peak performance. However, currently it is not known how ROS and calcium interact to maintain the system for optimal muscle contraction.
Her research aims to determine how calcium, ROS, and their interaction can alter muscle function in health and disease, via regulation of triadic microdomain homeostasis. To achieve this, my lab uses several techniques, including live-cell confocal microscopy of mechanically skinned and intact muscle fibres, western blotting, viral transductions and electroporation.
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